Table 2.

Effect of Coadministered Drugs on Exposure to Lurasidone in Healthy Subjects and in Patients with Schizophrenia

		Effect on Pharmacokinetics
Coadministered Drug	Dose Schedule	Lurasidone	Cmax	AUC	Recommendation
Ketoconazole (strong CYP3A4 inhibitor)	400 mg/day for 5 days	10 mg, single dose	6.9 times that of lurasidone alone	9 times that of lurasidone alone	Should not be coadministered with lurasidone
Diltiazem (moderate CYP3A4 inhibitor)	240 mg/day for 5 days	20 mg, single dose	2.1 times that of lurasidone alone	2.2 times that of lurasidone alone	Lurasidone dose should not exceed 40 mg/day if coadministered
Rifampin (strong CYP3A4 inducer)	600 mg/day for 8 days	40 mg, single dose	1/7 of lurasidone alone	1/5 of lurasidone alone	Should not be coadministered with lurasidone
Lithium	600 mg twice daily for 8 days	120 mg/day for 8 days	0.9 times that of lurasidone alone	1.1 times that of lurasidone alone	No dose adjustment required

AUC = area-under the curve concentration; C_max = peak concentration; CYP = cytochrome P450.

Data from Latuda product information, 2010.¹⁵