Table 1.
Group classification based on biological function of mRNAs that exhibit GCN2-dependent or PERK-dependent shift into polysomes in response to Met deprivation or tBuHQ treatment, respectively
| Biological Process | P Value | No. of mRNAs Affected |
|---|---|---|
| GCN2 dependent | ||
| Generation of precursor metabolites and energy | 1.50E-06 | 26 |
| Electron transport | 9.39E-06 | 21 |
| Lipid metabolism | 1.41E-04 | 20 |
| Blood coagulation | 3.92E-04 | 6 |
| Carbohydrate metabolism | 9.94E-03 | 11 |
| Death | 1.21E-02 | 13 |
| Proteolysis | 1.52E-02 | 18 |
| Endocytosis | 2.32E-02 | 7 |
| Steroid metabolism | 3.94E-02 | 5 |
| Alcohol metabolism | 4.34E-02 | 5 |
| PERK dependent | ||
| Response to biotic stimulus | 2.15E-06 | 26 |
| Electron transport | 1.17E-03 | 12 |
| Response to wound healing | 2.81E-03 | 9 |
| Response to stress | 5.71E-03 | 20 |
| Humoral immune response | 8.45E-03 | 5 |
| Protein folding | 1.25E-02 | 5 |
| Anion transport | 2.08E-02 | 6 |
| Translation | 2.44E-02 | 7 |
| Programmed cell death | 4.37E-02 | 12 |
GCN2, general control nonderepressible 2; PERK, double-stranded RNA-activated protein kinase (PKR)-like endoplasmic reticulum-resident kinase; tBuHQ, 2,5-di-tert-butylhydroquinone. The mRNAs in each category are listed in Supplemental Table S9.