Table 1.
In vitro cytotoxicity data as determined by XTT assay following a 72 h exposure. The data are expressed in μM as the mean ± standard error of 3 independent experiments. The IC50 is defined as the drug concentration that inhibits growth to 50% of the vehicle (DMSO)-treated control; IC50 values were calculated from sigmoidal analysis of the dose-response curves using Origin, version 7.5, software (OriginLab, Northampton, MA). ND, not determined. This assay was performed as previously reported.6
| Cell line | Cancer type | IC50 (μM)
|
|||
|---|---|---|---|---|---|
| E-26 | 5 | 6 | 7 | ||
| SK-MEL-2 | Melanoma | 10.71 ± 0.77 | >20 | 0.39 ± 0.11 | 0.70 ± 0.10 |
| JeKo-1 | Mantle cell lymphoma | 11.60 ± 0.27 | >20 | 0.11 ± 0.01 | 0.29 ± 0.02 |
| MOLT-4 | Acute lymphoblastic leukemia | 15.46 ± 0.76 | ND | 0.18 ± 0.01 | 0.66 ± 0.07 |
| PC-3 | Prostate | 18.03 ± 0.66 | >20 | 2.02 ± 0.39 | 4.16 ± 0.68 |
| MCF7 | Breast | 19.15 ± 0.55 | ND | 0.72 ± 0.02 | 1.69 ± 0.48 |
| NCI-H226 | Non-small cell lung cancer | >20 | ND | >10 | >10 |