Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The development of Torsades de Pointes (TdP) arrhythmia correlated better with the increase in short-term QT variability than with QTc changes in dogs. Two representative individual Poincaré plots show increased short-term variability of QT following combined IKr (by dofetilide) and IKs (by HMR-1556) block in a dog that later developed TdP (left panel) compared with a dog where TdP did not occur (right panel). From Lengyel et al. (2007a), with permission.
