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Repolarization (QTc) lengthening effect of eliprodil, a new investigational neuroprotective compound, in Langendorff-perfused rabbit hearts with normal and attenuated repolarization reserve (upper panel). Eliprodil never induced arrhythmias in normal hearts but often caused Torsades de Pointes (TdP) arrhythmias in preparations where repolarization reserve was reduced via Ik1 block by BaCl2 (lower panel). From Lengyel et al. (2004), with permission.
