Figure 3.
Effect of an adenosine A1 receptor selective antagonist on hypoxic depression. (A) The preparation isolated from postnatal day 5–8 (P5–8) rats was repeatedly exposed to hypoxia for 10 min each at 27°C and pretreated with 3 µM 8-cyclopentyl-1,3-dimethylxanthine (CPT) for 20 min before the third exposure. Then effects of hypoxia on monosynaptic reflex potential (MSR), slow ventral root potential (sVRP) and dorsal root potential (DRP) were observed in the presence of CPT. The number in the representative traces of reflex potentials (upper panel) correspond to those in the lower panel. (B) The effects of CPT on the hypoxia-evoked depression of MSR, sVRP and DRP in P5–8 rats at 27°C. Each symbol and error bar represents the mean ± SEM (n = 5–6).