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. 2011 Sep;22(9):1621–1630. doi: 10.1681/ASN.2010111146

Figure 6.

Figure 6.

High level of CA-RhoA expression induces FSGS. PAS staining of kidney sections is shown. (A) Double transgenic mice were treated with Dox or vehicle (−Dox) for 4 weeks. Glomeruli of low responders (middle) showed no abnormality and were not significantly different from vehicle-treated mice (top). Glomeruli of high responders (bottom) showed various degree of sclerosis. Note that cuboidal parietal glomerular epithelial cells (bottom) are often seen even in normal male mice. (B) Double transgenic mice were treated with Dox for 4 weeks, and then Dox was withdrawn (W). Kidneys were harvested 2 weeks later. Low responders (+Dox Low W, top) consistently showed normal kidney histology. Many high responders had a trend of declining albuminuria after withdrawal. PAS staining of these mice showed minimal sclerosis (+Dox High W, middle). Other high responders with sustained heavy albuminuria showed typical FSGS with interstitial leukocyte infiltration (arrow) (+Dox High W, bottom). Magnification, ×200 and ×600.