Table 4.
Renal function by treatment arm
| I. Geometric Mean Serum Cr Level */ SE (in mg/dl)1 | |||||||
|---|---|---|---|---|---|---|---|
| Post-Tx Month | N | TAC/SRL | N | TAC/MMF | N | CSA/SRL | P-Value |
| 12 | 48 | 1.40 */ 1.04 | 43 | 1.25 */ 1.05 | 45 | 1.48 */ 1.06 | 0.08 |
| 24 | 46 | 1.54 */ 1.07 | 45 | 1.31 */ 1.06 | 44 | 1.54 */ 1.05 | 0.07 |
| 36 | 41 | 1.39 */ 1.05 | 44 | 1.36 */ 1.06 | 44 | 1.60 */ 1.06 | 0.08 |
| 60 | 30 | 1.47 */ 1.09 | 26 | 1.33 */ 1.07 | 33 | 1.62 */ 1.07 | 0.19 |
| 84 | 27 | 1.38 */ 1.06 | 18 | 1.15 */ 1.08 | 27 | 1.44 */ 1.08 | 0.10 |
| II. Mean eGFR ± SE (in ml/min per 1.73 m2) Using the Abbreviated MDRD Formula | |||||||
|---|---|---|---|---|---|---|---|
| Post-Tx Month | N | TAC/SRL | N | TAC/MMF | N | CSA/SRL | P-Value |
| 12 | 48 | 58.3 ± 2.5 | 43 | 65.5 ± 3.7 | 45 | 55.1 ± 2.8 | 0.06 |
| 24 | 46 | 53.9 ± 2.7 | 45 | 62.5 ± 3.2 | 44 | 51.4 ± 2.5 | 0.02 |
| 36 | 41 | 58.6 ± 3.5 | 44 | 60.2 ± 3.2 | 44 | 50.4 ± 2.9 | 0.06 |
| 60 | 30 | 57.2 ± 4.4 | 26 | 59.1 ± 4.1 | 33 | 48.8 ± 3.0 | 0.12 |
| 84 | 27 | 59.5 ± 4.2 | 18 | 67.4 ± 6.2 | 27 | 53.8 ± 4.2 | 0.16 |
| III. Mean eGFR ± SE, stratifying by donor age | ||||||
|---|---|---|---|---|---|---|
| Donor Age <37.5 yr | ||||||
| Post-Tx Month | N | TAC/SRL | N | TAC/MMF | N | CSA/SRL |
| 12 | 28 | 62.8 ± 3.2 | 19 | 76.7 ± 6.2 | 23 | 63.0 ± 4.1 |
| 24 | 27 | 57.2 ± 3.8 | 19 | 70.6 ± 5.7 | 22 | 60.4 ± 3.5 |
| 36 | 25 | 64.1 ± 4.7 | 18 | 69.8 ± 4.8 | 22 | 59.7 ± 4.0 |
| 60 | 20 | 63.8 ± 5.8 | 11 | 66.9 ± 7.3 | 17 | 53.1 ± 4.7 |
| 84 | 19 | 65.2 ± 5.0 | 10 | 72.8 ± 10.0 | 15 | 60.5 ± 6.3 |
| Donor Age ≥37.5 yr | ||||||
| Post-Tx Month | N | TAC/SRL | N | TAC/MMF | N | CSA/SRL |
| 12 | 20 | 51.9 ± 3.7 | 24 | 56.6 ± 3.7 | 22 | 47.0 ± 3.1 |
| 24 | 19 | 49.1 ± 3.6 | 26 | 56.6 ± 3.3 | 22 | 42.4 ± 2.3 |
| 36 | 16 | 50.0 ± 4.2 | 26 | 53.5 ± 3.8 | 22 | 41.0 ± 3.1 |
| 60 | 10 | 43.9 ± 3.5 | 15 | 53.4 ± 4.4 | 16 | 44.2 ± 3.5 |
| 84 | 8 | 45.8 ± 5.5 | 8 | 60.7 ± 6.5 | 12 | 45.4 ± 4.1 |
Cr, creatinine; eGFR, estimated glomerular filtration rate; SE, standard error; TAC, Tacrolimus; MMF, mycophenolate mofetil; CSA, cyclosporine microemulsion; SRL, Sirolimus.
1Due to the skewness of each of the serum creatinine distributions, the geometric means rather than arithmetic means were reported. Proper assessment of variability requires that the geometric mean be multiplied and divided by its standard error.