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Myc-nick generation and regulation of cellular processes in the cytoplasm. Calpain-mediated cleavage of c-Myc results in the generation of Myc-nick. Myc-nick interacts with TRRAP and GCN5 and assists in the acetylation of tubulins, which results in more stable microtubular structures. The link between stable microtubule formation and MyoD-mediated gene transcription is currently unknown (indicated by the dashed lines). Ac, acetyl group.
