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. 2011 Sep 6;77(10):987–995. doi: 10.1212/WNL.0b013e31822e045c

Figure 1. Effect of all-trans retinoic acid (ATRA) on nerve growth factor (NGF) contents and retinoic acid receptor (RAR)-β expression in sciatic nerve.

Figure 1

(A) Content of NGF in sciatic nerve. ATRA increased NGF content in sciatic nerve of rat treated with chemotherapy. *p < 0.001 when compared with cisplatin, cisplatin/ATRA, and paclitaxel; **p = 0.004 when compared with paclitaxel/ATRA; ***p < 0.0001 when compared with cisplatin; ****p = 0.052 when compared with paclitaxel. (B) Percentage of RAR-β expression in sciatic nerve. (C) Relative quantification of RAR-β expressed by logarithm base 10. RAR-β is not expressed in peripheral nerve control group but ATRA increased its expression in rats treated with chemotherapy. *p = 0.22 when compared with cisplatin; **p < 0.001 when compared with paclitaxel.