Table 3.

Influence of non-genetic factors on CYP1A2 phenotype.

Non-genetic factora	Correlation testb	mRNAc	Proteinc	Activityc
Sex	K	0.26	0.68	0.99
Age	S	0.27	0.045	0.24
NIC	K	0.018	0.001	0.0004
ALC	K	0.30	0.50	0.71
IND	K	0.38	0.025	0.03
BILI	K	0.001	0.0002	0.0005
GGT	K	0.11	0.001	0.009
CRP	K	0.32	0.015	0.03
DIAG	K	0.08	0.09	0.009
Chol	K	0.06	0.008	0.004

^aNIC, nicotine consumption: non smokers vs. smokers (>1 cigarets/day); ALC, alcohol consumption: none vs. >1 times/week; IND, exposure to known inducers of P450; BILI, serum total bilirubin; GGT, serum gamma glutamyl transferase; CRP, C-reactive protein; DIAG, diagnosis; Chol, cholestasis.

^bKnuskal-Wallis (K) or Spearman correlation (S) test.

^cp-Values for univariate analyses using the given correlation test. Results were not corrected for multiple testing.