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. Author manuscript; available in PMC: 2011 Sep 13.
Published in final edited form as: Mol Ther. 2007 Mar 13;15(6):1211–1219. doi: 10.1038/sj.mt.6300121

Figure 1. Schematic diagrams of the invariant (Ii) chain and the chimeric Ii–Pan HLA-DR reactive epitope (PADRE).

Figure 1

(a) Diagram of the Ii chain. The blue region indicates the location of the class II–associated Ii peptide (CLIP) (aa81–102). (b) Diagram of the Ii-PADRE chimeric protein. The red region indicates the location of PADRE, which replaces the CLIP region of the Ii chain. (c) Diagram of a typical major histocompatibility complex (MHC) class II molecule associated with the Ii chain. The CLIP region of the Ii chain occupies the peptide-binding site and is eventually replaced by an antigenic peptide in the endosomal/lysosomal compartments. (d) Diagram of an MHC class II molecule associated with the Ii-PADRE chimeric protein. The PADRE peptide remains attached to the peptide-binding site of the MHC class II molecule.

HHS Vulnerability Disclosure