Table 1.
Estimated pharmacokinetic/pharmacodynamic parameters from clarithromycin concentrations measured in infected mice serum and bronchoalveolar lavage on the third day of treatment in three or four mice per dosage at 1, 2, 4, 10 and 24 h after the third daily administration of clarithromycin
| Clarithromycin dose |
||||||
|---|---|---|---|---|---|---|
| 10 mg/kg |
25 mg/kg |
75 mg/kg |
||||
| PK/PD parameter | serum | BAL | serum | BAL | serum | BAL |
| 1 h concentration (mg/L) | 0.988 | 0.047 | 2.222 | 0.146 | 8.875 | 0.602 |
| AUC0–24 (mg·h/L) | 2.41 | 0.12 | 7.57 | 0.41 | 30.03 | 2.08 |
| 1 h concentration/MIC | 124.8 | 5.9 | 277.8 | 18.3 | 1109.3 | 75.3 |
| Time above MIC | 92.1% | 26.3% | 97.1% | 35.8% | 99.6% | 58.3% |
| AUC0–24/MIC | 301.1 | 14.5 | 947.0 | 50.6 | 3753.8 | 259.6 |
PK/PD, pharmacokinetic/pharmacodynamic; BAL, bronchoalveolar lavage.
MIC for the M. pneumoniae strain used in the experiment was ≤0.008 mg/L (0.008 mg/L used for MIC value for calculations).