Table 1.

Effects of different antihypertensive agents on arterial stiffness

Class	Effect on Ao-PWV	Effect on central aortic pressures and AIx
Thiazide diuretics24	Neutral	Neutral
α-blockers
Doxazosin37,38	Neutral	Neutral
β-blockers
Atenolol25,28,29	Reduce	Increase
Nebivolol,35 vasodilating	Reduce	Reduce
β-blocker
CCB23,28,32	Reduce	Reduce
RAAS blockers
Aldosterone antagonists32	Reduce	Reduce
ACE-I28,33	Reduce	Reduce
ARB23,29,33	Reduce	Reduce

Abbreviations: ACE-I, ACE inhibitor; ARB, angiotensin receptor blocker; AIx, augmentation index; Ao-PWV, aortic pulse wave velocity; CCB, calcium channel blocker; RAAS, renin–angiotensin–aldosterone system.