Table 2.
Effects of combination therapy of different classes of antihypertensive agents on arterial stiffness
| Combination | Effect on Ao-PWV | Effect on central aortic pressures and AIx |
|---|---|---|
| ACE-I + CCB6 | Neutral | Reduce |
| Thiazide + potassium-sparing (amiloride) diuretic26,27 | Neutral | Reduce |
| ACE-I + indapamide25 | Reduce | Reduce |
| ARB + CCB24 | Reduce | Reduce |
| ARB + thiazide diuretic23 | Reduce | Reduce |
Abbreviations: ACE-I, ACE inhibitor; ARB, angiotensin receptor blocker; AIx, augmentation index; Ao-PWV, aortic pulse wave velocity; CCB, calcium channel blocker.