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. 1999 Dec 15;13(24):3231–3243. doi: 10.1101/gad.13.24.3231

Figure 1.

Figure 1

Dach2 is a vertebrate homolog of Drosophila dachshund. (A) Comparison of chick Dach2 and Drosophila dachshund putative amino acid sequences. Identical amino acids are marked with a dot over the amino acid. Two highly conserved regions are marked by a box. The amino-terminal box corresponds to DD1/Dachbox1, whereas the carboxy-terminal box corresponds to DD2/Dachbox2 (see text for details). Similarities in these two regions are 86% and 70%, respectively. (B) Northern blot on stage 22 embryo total RNA showing a single band, approximately 3 kb, hybridizing with a Dach2 probe. Compare with the 2.8-kb band in the RNA ladder. (C) Dach2 misexpression can compensate for the loss of dachshund in dac mutant lines. (i,iv) Wild-type eye; (ii,v) dac mutant eyes; (iii,vi) Dach2 expressed ectopically in a dac mutant background using Drosophila dac::Dach2 fusion transgene driven by dac–GAL4. (i–iii) Scanning electron microscopy images of Drosophila eyes. (iv–vi) Drosophila eye discs stained for dpp expression in blue (to mark the morphogenetic furrow) and Elav expression in orange (to mark photoreceptors).