Table 2.

Antihypertensive efficacy of irbesartan, comparing oral irbesartan monotherapy with other classes of antihypertensive drugs in patients with mild-to-moderate hypertension

Comparison class (agent)	Dosage (mg/day)	IRB noninferior	IRB superior	IRB inferior
ACE inhibitor
ENA	IRB 150–300, ENA 10–20	Chiou et al27
	IRB 150–300, ENA 10–20	Coca et al22
	IRB 150–300, ENA 10–20	Lacourciere20
	IRB 75–300, ENA 5–10	Mimran et al21
Renin inhibitor
ALI	IRB 150, ALI 150	Gradman et al36
	IRB 150, ALI 300			Gradman et al36
Calcium channel blocker
AML	IRB 150, AML 5	Gaudio et al61
Beta-blocker
ATE	IRB 75–150, ATE 50–100	Stumpe et al28
Alpha-1 antagonist
DOX	IRB 300, DOX 4		Derosa et al38
Angiotensin II receptor blockers
LOS	IRB 150, LOS 100		Kassler-Taub et al24
	IRB 300, LOS 100	Kassler-Taub et al24
	IRB 200, LOS 100	Yoshinaga91
	IRB 150–300, LOS 50–100	Oparil et al25
VAL	IRB 150, VAL 80		Mancia et al23
OLM	IRB 150, OLM 20			Oparil et al39

Abbreviations: ACE, angiotensin-converting enzyme inhibitor; CCB, calcium channel blocker; BB, beta blocker; ATE, atenolol; IRB, irbesartan; ENA, enalapril; ALI, aliskiren; AML, amlodipine; LOS, losartan; OLM, olmesartan; VAL, valsartan; DOX, doxazosin.