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Role of PTP opening in donut formation. (a) Effect of mastoparan (Mas, 5 μM) on ΔΨm, mitochondrial morphology and Opa1 cleavage. (b) Effect of CSA, Me-Val-CSA (mCSA) and FK506 on the FCCP-induced donut formation and Opa1 cleavage. (c) Effect of CSA on the hypoxia–reoxygenation (H–R) induced donut formation (*P⩽0.001)
