Figure 8.

A possible model of cellular functions of bifunctional Prdx6 with peroxidase and PLA₂ activities. The peroxidase of Prdx6 acts to eliminate the increased intracellular H₂O₂ induced by a variety of stimuli and thereby has a key role in the protection against cellular damages in oxidative stress, as shown in the current work and many previous reports. Other cellular functions of the PLA₂ activity of Prdx6 may be involved in the TNF-induced apoptosis and the proinflammatory response. PLA₂ induces the release of AA, which is involved in the inflammatory response by its metabolic mediator or in apoptosis linked with a caspase-dependent pathway. In addition, PLA₂ induces the activation of IL-1β-converting enzyme and caspase-1, and in turn regulates the production of IL-β. IL-1β as a potential proinflammatory cytokine is involved in the inflammatory response