Figure 8.

Insulin tolerance tests in wild-type (○) and transgenic aP2-SREBP-1c436 (•) mice. Ad-libitum fed animals were injected intraperitoneally with human crystalline insulin in the middle of the light cycle as described in Materials and Methods, and blood was taken at the indicated time for measurement of glucose content. Results are expressed as percent of the plasma glucose concentration at zero time and are plotted as mean ±s.e.m. of the indicated number of animals. The zero-time plasma glucose levels were as follows: Exp. 1, 164 ± 23 and 310 ± 38 mg/dl in wild-type and transgenic mice, respectively; Exp. 2, 163 ± 11 and 412 ± 72; Exp. 3, 183 ± 7 and 279 ± 91.