Scheme 3.
(i) NEt3, MeMgBr, PhMe, THF, 0 °C, 46%; (ii) (R)-1-methyl-3,3-diphenylhexahydro-pyrrolo[1,2-c][1,3,2]oxazaborole, BH3·SMe2, PhMe, THF, 0 °C, 84%; (iii) NEt3, MsCl, CH2Cl2; (iv) DIEA, DMSO, 90 °C, 60%; (v) MeN=C=S, H2O, NaOH, 50 °C.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.