. 2011 Apr 15;2(8):411–432. doi: 10.1021/cn2000266

Table 11. Functional mGlu₅ Activity in the Nicotinamide Series.

graphic file with name cn-2011-000266_0031.jpg

entry	n	X	A	R	mGlu₅ IC₅₀ (nM)
171	1	H	CH	Cl	310
172	0	H	CH	Cl	5400
173	2	H	CH	Cl	250
174	3	H	CH	Cl	2300
175	1	H	CH	H	∼10 000
176	1	H	CH	F	2300
177	1	H	CH	Me	2300
178	1	H	CH	OMe	1800
179	1	H	N	Me	420
180	1	Cl	CH	Cl	95
181	1	Cl	N	Me	87

Table 11. Functional mGlu5 Activity in the Nicotinamide Series.