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| entry | n | X | Y | Z | R | mGlu5 IC50 (nM) |
|---|---|---|---|---|---|---|
| 201 | 1 | O | C | N | H | 60 |
| 202 | 1 | N | C | O | H | 290 |
| 203 | 1 | O | C | N | F | 28 |
| 204 | 1 | N | C | O | F | 54 |
| 205 | 1 | N | C | NH | F | 34% at 10 μM |
| 206 | 1 | N | C | S | F | 52% at 10 μM |
| 207 | 1 | C | N | N | F | 153 |
| 208 | 1 | N | N | N | F | 346 |
| 209 | 2 | O | C | N | H | 65 |
| 210 | 2 | O | C | N | F | 16 |
