Table 18. mGlu5 Potency in Oxadiazole Series.
| entry | R1 | R2 | mGlu5 IC50 (nM) |
|---|---|---|---|
| 256 | OMe | OMe | 62 |
| 257 | H | CF3 | 2360 |
| 258 | H | Cl | 240 |
| 259 | H | Br | 215 |
| 260 | F | CN | 24 |
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