Table 2. SAR of 5,6-Fused Ring Heterocycles.

^aR = 3-Cyano-5-fluorophenyl.

^bCalcium mobilization mGlu₅ assay; values are average of n ≥ 3.

^cAmplitude of response in the presence of 30 μM test compound as a percentage of maximal response (100 μM glutamate); values are average of n ≥ 3.

^dCRC does not plateau.

^eReaction of 21 with K₂CO₃ and MeI in DMF afforded a separable mixture of 22 and 23