Table 4. In Vitro DMPK Profile of 18.
| metabolic stability in liver microsomes | |
|---|---|
| species | % parent remaining |
| mouse | 18 |
| human | 20 |
| protein binding | |
|---|---|
| sample | % bound |
| mouse brain homogenate | 99.9 |
| mouse plasma | 99.5 |
| human plasma | 99.4 |
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