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. 2011 Sep 13;9(9):e1001148. doi: 10.1371/journal.pbio.1001148

Figure 2. CD81 is essential for maintaining HSC self-renewal.

Figure 2

(A) Cd81 −/− HSCs show comparable engraftment capacity in primary competitive transplantation assays, in which 300 HSCs (CD45.2+SPKLS) were transplanted with 2.2×105 wild-type (WT) competitors (CD45.1) into lethally irradiated mice (CD45.1+). Peripheral blood engraftment was measured at the indicated time points. Mean values ± 50 are shown (n = 3). (B) Cd81 −/− HSCs showed only minimal levels of engraftment in secondary competitive transplantation assays, in which 300 donor-derived HSCs (CD45.2+SPKLS) were purified from the primary recipients 21 wk after primary transplantation and transplanted along with 2×105 wild-type competitors into lethally irradiated mice. Mean values ± SD are shown (n = 10, **p<0.01).