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. 2011 Sep 13;6(9):e23818. doi: 10.1371/journal.pone.0023818

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Bish et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A.) Representative Western blot for MEF-2, a transcriptional factor for myostatin, in Adult Normal (n = 5), pediatric right ventricular outflow tract (RVOT) (n = 3), pediatric orthotopic heart transplant (OHT) (n = 7 paired LV and RV), and pediatric biventricular assist device (BiVAD) myocardial tissue samples (n = 3 paired LV and RV). B.) MEF-2 was significantly increased in LV-OHT compared to Adult Normal control (#p<0.05). In addition, BiVAD support increased MEF-2 significantly over all patient groups in both RV and LV samples (*p<0.05 vs. Adult Normal, RVOT, RV-OHT, LV-OHT).