FIGURE 1:

Tissue-specific rescue of the dumpy phenotype of ten-1(ok641) phy-1(ok162) double mutants. Transgenic and nontransgenic animals of the same population of each rescue line are shown. The dumpy phenotype is rescued by expression of phy-1 under the control of its endogenous promoter (Pphy-1::phy-1) (A) (coinjection marker unc-122::gfp is expressed only in the coelomocytes) or by an epidermal specific promoter (Peff-1::phy-1::gfp) (B). Expression driven by a muscle-specific promoter (Pmyo-3::phy-1::gfp) does not rescue the dumpy phenotype (C) but rescues the embryonic lethality (see Table 1). Scale bar, 100 μm.