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. 2011 Sep 15;22(18):3331–3343. doi: 10.1091/mbc.E10-10-0853

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© 2011 Topf and Chiquet-Ehrismann. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — Basement membrane integrity is affected in arrested ten-1 phy-1 mutant embryos. Localization of LAM-1 fused to GFP in a single focal plane (left) and merged with the corresponding differential interference contrast image (right). (A, B) Laminin is localized to BMs of the pharynx (pha), intestine (int), and developing gonad (not in focus) of a threefold wild-type embryo. (C, D) Disruption and disorganization of the pharyngeal BM in arrested ten-1 phy-1 embryos. Laminin is generally localized correctly. (E, F) Localization of laminin to the BM between the hypodermis and body wall muscles in a threefold wild-type embryo. One muscle strand is in focus. (G, H) The BM between body wall muscles and hypodermis shows breaks in double-mutant embryos (arrowheads). Corresponding images of threefold embryos of ten-1(ok641) and phy-1(ok162) single mutants are presented in Supplemental Figure S3. Scale bar 10, μm.