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. 1998 Nov 1;12(21):3357–3368. doi: 10.1101/gad.12.21.3357

Figure 5.

Figure 5

Identification of critical carboxy-terminal residues in the NCoA-1/SRC-1 LXD2 motif for function in transcriptional activation by ER from an expression plasmid (A), or endogenous RAR (B). In each case, the ability of NCoA-1/SRC-1 wild-type, LXD2 mutant (LAAAA), or NCoA-1 proteins with single amino acid alanine substitutions [LXD2(+6)mut through LXD2(+13)mut] were evaluated by use of the single cell microinjection assay. The critical amino acids differed in the case of ER and RAR; mean ± s.e.m.