TABLE 1:
S. cerevisiae genes deleted for UPR induction in this study
| Processing or folding of secretory proteins in the ER | |
| SCJ1 | Co-chaperone of BiP |
| SPC2 | Subunit of signal peptidase |
| Glycosylation | |
| ALG3 | Synthesis of oligosaccharide donor for N-linked glycosylation of proteins |
| EOS1 | N-linked glycosylation |
| PMT2 | Protein O-mannosyltransferase |
| Vesicle transport and related events | |
| ERV14 | Cargo receptor in ER-to-Golgi transport |
| ERV25 | Cargo receptor in ER-to-Golgi transport |
| SEC28 | Subunit of COPI vesicle coat |
| GPI-anchor production | |
| BST1 | GPI inositol deacylase |
| LAS21 | Synthesis of the GPI core structure |
| Lipid metabolism and homeostasis | |
| ARV1 | Intracellular transport of lipidic components |
| OPI3 | Phosphatidylcholine biosynthesis |
| SCS3 | FIT family protein (triglyceride droplet biosynthesis) |
| ISC1 | Phosphosphingolipid phospholipase C |
| MGA2 | Transcriptional regulation of OLE1 encoding δ9 fatty acid desaturase |
| Other function related to ER membrane | |
| GET1 | Insertion of tail-anchored proteins into the ER membrane from cytosol |
| Unknown function | |
| STE24 | Zinc metalloprotease |
| ERD1 | Retention of BiP in the ER |
Gene functions described here are based on SGD.