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. 2011 Sep 13;6(9):e24844. doi: 10.1371/journal.pone.0024844

Figure 3. Structure and Anti-Prion Activity of Fluphenazine.

Figure 3

Fluphenazine. A) Shows the structure of fluphenazine. Fluphenazine was applied to N2a/22L for 72 hrs at 0.1, 0.5, 1.0 and 2.5 µM. B) Western blot of PK-digested cell lysates. C) Bar graph representation of PrPSc reduction. Fluphenazine reduces PrPSc infectivity by 84.8%, 75.5%, 24.0% and 2.9% respectively. Differences are significant by One-way ANOVA (***p<0.0001), and *p<0.05 Newman-Keuls post-hoc analysis versus N2a/22L as indicated on the graph.