Table 1.
Analysis of progeny from heterozygote matings (Gdf7m1/+ × Gdf7m1/+)
| +/+
|
+/−
|
−/−
|
Hydrocephalic −/Ü% of total −/−)
|
|---|---|---|---|
| No. of progeny: mixed background (129Sv × C57BL/6) | |||
| 66 (26%) | 127 (50%) | 60 (24%) | 22 (37%) |
| No. of progeny: inbred background (129Sv) | |||
| 15 (24%) | 32 (52%) | 15 (24%) | 3 (20%) |
Animals were genotyped ∼10 days after birth. No differences were noted in the results of crosses of animals that derive from two independent ES cell targeting events, and both sets of results are combined here. Hydrocephalus was not observed in any wild-type or heterozygous animals in these crosses.