Figure 6. Influence of protein kinases inhibitors on ARE-dependent luciferase expression induced by HCV proteins.

Histograms of relative luciferase activity in Huh7 cells expressing HCV core, E1, E2, NS4B, or NS5A proteins, treated with commercially available inhibitors of PI3K (wortmannin, Wo), CK2 (DRB), or PKC (Ro 31-8220, Ro). In a parallel experiment the cells were pre-treated with ROS scavenger PDTC. The control cells were treated with DMSO. Error bars indicate SD.