Figure 3. Oral Pravastatin Promotes the Outgrowth of LOEPCs from Blood Mononuclear Cells.

Pigs were treated with a placebo or pravastatin (4 mg/kg orally) daily for three consecutive days. Blood mononuclear cells were obtained on day three, and cultured on type I collagen coated dishes to derive LOEPCs. The quantity of LOEPCs per 3×10⁷MNCs plated was determined using flow cytometry to determine the number of PECAM positive cells after 14 days in culture. The data are presented as the means ± SEM from eight different animals. * p<0.01 vs. control using a paired t-test.