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. Author manuscript; available in PMC: 2012 Sep 20.
Published in final edited form as: Biochemistry. 2011 Aug 24;50(37):8028–8037. doi: 10.1021/bi2008189

Figure 8.

Figure 8

Stimulating effect of various αC-fragments on activation of plasminogen by tPA. Stimulating effect of cross-linked Aα221-610 oligomers (circles), cross-linked Aα221-610 monomer (triangles up), Aα221-610 monomer (triangles down), and fibrinogen (diamonds) was measured by hydrolysis of chromogenic substrate S-2251 with newly formed plasmin as described in Experimental Procedures. The activation of plasminogen in the absence of stimulators is shown by empty circles. Each point represents the mean ± S.D. of 3 independent experiments.