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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Pharmacogenet Genomics. 2011 Oct;21(10):652–664. doi: 10.1097/FPC.0b013e3283498ee9

Figure 5.

Figure 5

NAT1 protein level/enzyme activity and NAT1 genotype. a. NAT1 protein levels in livers measured by Western blot. NAT1 immunoreactivities were quantitated in livers with different NAT1 genotypes, using GAPDH as internal control. * p<0.05 compared to *4/*4, ANOVA with Dunnett post test. Western blots were run for each sample separately, and quantitative data are shown in bar graph form. Upper panel shows a Western blot image of pooled samples. Same protein amounts from each liver in the same group were pooled and analyzed by Western blot. As control, Western blots were also run for cell lysates from NAT1 or NAT2 transfected cells. The antibody can only detect NAT1 but not NAT2. b. NAT1 enzyme activities in B-lymphocytes grouped by NAT1 genotypes. NAT1 enzyme activities in cell cytosol were measured using PABA as substrate. *Compared to *4/*4, p<0.001, ANOVA with Dunnett post test.