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. 1998 Nov 1;12(21):3343–3356. doi: 10.1101/gad.12.21.3343

Figure 1.

Figure 1

(a) Functional domains of p160 family coactivators (Ding et al. 1998; Voegel et al. 1998). (b) The NID of GRIP1 (563–767) contains four predicted α-helices (Rost and Sander 1994); three of them include the conserved LxxLL motifs of NR-boxes 1, 2, and 3. (c) Sequence alignment of LxxLL motifs in members of the p160 coactivator family. Motif leucine residues are green; box-specific conserved residues are red. GRIP1 (Hong et al. 1996, 1997), pCIP (Torchia et al. 1997), and SRC-1 (Oñate et al. 1995) were taken as representatives for the three distinct classes of coactivators in the p160 family. Predicted α-helices are shown for each box.