Table 2.

Subgroup analysis of ApoE genotypes and Parkinson disease

	Case /control	ε4/4+ε3/4 vs ε3/3	p	Case /control	ε2/2+ε2/3 vs ε3/3	p	Case /control	ε2/4 vs ε3/3	p
Year of birth
≤1931	329/688	0.76 (0.55–1.05)	0.10	324/632	1.06 (0.75–1.51)	0.75	268/529	0.72 (0.28–1.85)	0.50
>1931	337/605	0.73 (0.53–1.02)	0.06	304/530	0.83 (0.55–1.26)	0.38	268/457	0.66 (0.26–1.69)	0.39
Gender
Men	507/1026	0.72 (0.55–0.94)	0.02	486/924	0.99 (0.73–1.34)	0.96	415/787	0.86 (0.41–1.82)	0.70
Women	159/267	0.81 (0.50–1.31)	0.39	142/238	0.78 (0.44–1.40)	0.41	121/199	0.42 (0.10–1.71)	0.23
Smoking status
Never	310/456	0.70 (0.49–0.99)	0.04	292/397	1.07 (0.70–1.62)	0.77	250/342	0.72 (0.28–1.87)	0.50
Ever	348/821	0.78 (0.57–1.07)	0.12	329/752	0.87 (0.61–1.24)	0.44	277/631	0.54 (0.20–1.48)	0.23
Caffeine intake
Below median	365/608	0.82 (0.60–1.12)	0.22	347/543	1.11 (0.77–1.60)	0.57	291/462	0.80 (0.33–1.93)	0.62
Above median	301/685	0.67 (0.48–0.95)	0.02	281/619	0.80 (0.53–1.19)	0.27	245/524	0.60 (0.22–1.69)	0.33
Family History
Yes	93/70	0.69 (0.32–1.48)	0.34	86/62	0.94 (0.38 2.30)	0.89	74/50	1.77 (0.16–19.1)	0.64
No	566/1113	0.75 (0.59–0.96)	0.02	537/997	0.98 (0.74–1.30)	0.89	457/854	0.63 (0.31–1.29)	0.21

Adjusted for Year of birth, gender, smoking status, daily caffeine intake and family history of PD; P values were not adjusted for multiple comparison.