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. Author manuscript; available in PMC: 2012 Sep 20.
Published in final edited form as: Biochemistry. 2011 Aug 26;50(37):8057–8066. doi: 10.1021/bi200573t

Figure 1. Human BCRP topology (A) and sequence alignment (B).

Figure 1

A) The boundary of TM helices is based on the experimentally determined membrane topology of BCRP and only the MSD is shown. Proline residues analyzed in this study are circled and indicated with amino acid positions. B) Human BCRP amino acid sequence in the TM helices was aligned with the corresponding sequences of BCRP homologs and orthologs using Clustal W. Proline residues analyzed in this study are highlighted.