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. 1998 Nov 15;12(22):3613–3624. doi: 10.1101/gad.12.22.3613

Figure 5.

Figure 5

Ectopic expression of vnd suppresses the identity of intermediate and dorsal NE and Nbs. (A,B) Vnd suppresses Hkb expression in the intermediate and dorsal neuroblasts. (A) In stage 11 wild-type embryos, Hkb protein is strongly expressed by Nb 2-4 (arrowhead), Nb 4-2 (arrow), Nb 4-4, and Nb 5-4. (B) In sca–GAL4; UAS–vnd embryos, the Hkb-positive Nb4-2 and Nb2-4 are missing. Other Hkb-positive Nbs are out of focus and are weakly stained. (C) Kr–GAL4; UAS–vnd embryos double stained for Lbe and Engrailed. Outside the Kr domain, Nb 5-6 expressing Lbe (arrow) is detected just above the Engrailed stripe. Within the Kr domain, Lbe expression in Nb 5-6 is abolished. (D) Kr–GAL4; UAS–vnd embryos carrying a msh–lacZ insertion and stained for β-gal to detect msh expression. Early msh expression in the dorsal column of the NE is abolished within the Kr domain.