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. 1998 Dec 1;12(23):3715–3727. doi: 10.1101/gad.12.23.3715

Figure 3.

Figure 3

Figure 3

Alignment of predicted PIWI protein sequence with its homologs. (A) Sequence alignment of predicted PIWI proteins from Drosophila (PIWI), C. elegans (PRG-1 and PRG-2) and human (HIWI). The full-length amino acid sequence of PRG-1 and PRG-2 was deduced from the nucleotide sequence of two independent cDNA clones. Partial amino acid sequence of HIWI was deduced from the nucleotide sequence of a partial cDNA clone from a human testes library. The alignments were produced with CLUSTALW software (DNAStar). Identical residues to a consensus are highlighted. (B) The piwi box domain in 22 different proteins. The alignments were generated by Block Maker analysis (Henikoff et al. 1995) against amino acids 740–782 of the predicted piwi sequence. The amino acid sequences were deduced from genomic DNA sequences for C. elegans (Ce G) or from cDNA (EST) sequences (E) for Rattus sp. (Rs) and Oryza sativa (Os). GenBank accession numbers and cosmid designations (Ce) are indicated for each sequence. Residues identical to the consensus are highlighted. Shown below the alignments: Residues that are absolutely conserved are shown as uppercase letters and residues that are 80% or more conserved are shown as lowercase letters; dashes indicate spacing.