Table 3.

Joint Associations With Mortality of Change in Adiponectin and Change in Inflammatory Markers According to the Upper Quartile of Their Distributions

	No. Deaths/No. at Risk	Incidence Rate*	Adjusted HR†(95% CI)	p
ΔAdiponectin and ΔCRP‡
Low ΔAPN, low ΔCRP	66/466	40.3 (31.7–51.4)	1.00 (referent)	—
Low ΔAPN, high ΔCRP	41/164	77.4 (57.0–105)	1.98 (1.33–2.96)	.001
High ΔAPN, low ΔCRP	46/164	85.9 (64.4–114)	1.53 (1.03–2.29)	.036
High ΔAPN, high ΔCRP	23/46	190 (126–286)	2.48 (1.47–4.21)	.001
Interaction p value				.56
ΔAdiponectin and ΔIL-6‡
Low ΔAPN, low ΔIL-6	65/482	38.4 (30.1–48.9)	1.00 (referent)	—
Low ΔAPN, high ΔIL-6	42/148	89.0 (65.8–120)	2.20 (1.47–3.28)	<.001
High ΔAPN, low ΔIL-6	38/148	78.1 (56.8–107)	1.51 (1.00–2.32)	.053
High ΔAPN, high ΔIL-6	31/62	183 (129–260)	2.49 (1.54–4.03)	<.001
Interaction p value				.38

Notes: CI = confidence interval; HR = hazard ratio; CRP = C-reactive protein; IL-6 = interleukin 6.

^*Per 1,000 person-years.

^†Compared with referent category having both biomarkers in the bottom three quartiles. Adjusted for same covariates as in Table 2.

^‡Cut-points for high change based on upper quartile vs lower three quartiles: adiponectin (≥5.1 mg/L), CRP (≥0.9 mg/L), and IL-6 (≥1.9 pg/mL).