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. Author manuscript; available in PMC: 2012 Sep 7.
Published in final edited form as: Cell Metab. 2011 Sep 7;14(3):301–312. doi: 10.1016/j.cmet.2011.06.014

Figure 2. SIRT1 in SF1 neurons is required for normal defenses against diet-induced obesity in male and female mice.

Figure 2

(A) Body weight curves of standard chow (SC)-fed Sirt1loxP/loxP (n=21) and Sf1-Cre, Sirt1loxP/loxP (n=21) males, high-calorie (HC)-fed Sirt1loxP/loxP (n=16) and Sf1-Cre, Sirt1loxP/loxP (n=24) males, (B) SC-fed Sirt1loxP/loxP (n=16) and Sf1-Cre, Sirt1loxP/loxP (n=13) females, HC-fed Sirt1loxP/loxP (n=14) and Sf1-Cre,Sirt1loxP/loxP (n=14) females. (C) Body composition, (D) representative micro-computed tomography images, and (E) serum leptin levels of Sirt1loxP/loxP and Sf1-Cre, Sirt1loxP/loxP mice; data shown in C, D, and E were gathered from 28-week-old females and 48-week-old males (n=13-17). In (D) red and yellow/green colors represent lean and fat mass, respectively; females are shown. Error bars represent s.e.m. Statistical analyses were done using two-tailed unpaired Student's t test. #P=0.05; *P<0.05; **P<0.01; #P=0.05. See also Table S1.