Table 2.

Change in Primary and Secondary Efficacy Measures

Change in scores from Baseline to Study Endpoint (LOCF)	Placebo (n=16)	Lamotrigine (n=16)	Statistic *	Df	p-value
NE-YBOCS Total - change
Mean (± SD), Median [range]	−3.37 (10.50) −2.50 [−23, 20]	−4.25 (5.50) −5.15 [−10, 6]	−.299t	30	.767
NE-YBOCS Thoughts/Urge - change
Mean (± SD), Median [range]	−1.00 (6.47) −1.00 [−11, 16]	−1.625 (3.24) −1.00 [−7, 4]	−.345t	30	.732
NE-YBOCS Behavior - change
Mean (± SD), Median [range]	−2.37 (4.95) −1.50 [−13, 4]	−2.62 (4.45) −3.00 [−11, 7]	−.150t	30	.882
Skin Pick Scale -change
Mean (± SD), Median [range]	−2.18 (4.86) −1.50 [−11, 6]	−3.62 (3.98) −3.00 [−12, 3]	−.915t	30	.367
SP-SAS -change
Mean (± SD), Median [range]	−5.43 (10.26) −4.00 [−28, 13]	−7.59 (9.29) −8.00 [−30, 8]	−.623t	30	.538
CGI Severity - change
Mean (± SD), Median [range]	−.250 (1.29) .00 [−4, 2]	−.500 (.81) .00 [−2, 1]	−.655t	30	.518
SDS -change
Mean (± SD), Median [range]	−7.37 (6.70) −4.00 [−19, 0]	−7.62 (5.57) −7.50 [−17, 0]	−.132z	n/a	.895
HAM-D - change
Mean (± SD), Median [range]	−.125 (1.14) .00 [−2, 2]	−1.31 (2.91) −1.50 [−6, 4]	−1.516t	30	.140
HAM-A - change
Mean (± SD), Median [range]	−.312 (1.81) .00 [−4, 3]	−1.06 (2.81) −1.00 [−7, 5]	−.750t	30	.353

^*Statistic: t = t-test z = Mann-Whitney

Intent-to-treat with last observation carried forward

Abbreviations: NE-YBOCS = Yale Brown Obsessive Compulsive Scale Modified for Neurotic Excoriation; SP-SAS = Skin Picking Symptom Assessment Scale; CGI = Clinical Global Impression severity scale; SDS= Sheehan Disability Scale; HAM-D= Hamilton Depression Scale; HAM-A= Hamilton Anxiety Scale; n/a = not applicable