Table 3.
General Linear Model of Primary and Secondary Measures
| Variable | Degrees Freedom | F-Statistic | P-Value | Effect Size Partial-Eta Squared | Observed Power | |
|---|---|---|---|---|---|---|
| NE-YBOCS Total | NE-YBOCS Total - Trend | (1,30) | 6.791 | .014 | NS | .713 |
| Interaction | (1,30) | .089 | .767 | NS | .060 | |
| Arm of Study | (1,30) | 2.891 | .099 | .132 | .377 | |
| NE-YBOCS Thoughts/Urge | NE-YBOCS Thoughts/Urge - Trend | (1,30) | 2.105 | .157 | .231 | .290 |
| Interaction | (1,30) | .119 | .732 | NS | .063 | |
| Arm of Study | (1,30) | 4.555 | .041 | NS | .542 | |
| NE-YBOCS Behavior | NE-YBOCS Behavior - Trend | (1,30) | 9.016 | .005 | .185 | .828 |
| Interaction | (1,30) | .023 | .882 | NS | .052 | |
| Arm of Study | (1,30) | .609 | .441 | NS | .118 | |
| Skin Picking Scale | Skin Picking Scale - Trend | (1,30) | 13.692 | .001 | NS | .947 |
| Interaction | (1,30) | .837 | .367 | NS | .144 | |
| Arm of Study | (1,30) | .124 | .727 | NS | .063 | |
| SP-SAS | SP-SAS - Trend | (1,30) | 14.168 | .001 | NS | .954 |
| Interaction | (1,30) | .388 | .538 | NS | .093 | |
| Arm of Study | (1,30) | .033 | .858 | NS | .054 | |
| CGI Severity | CGI Severity -Trend | (1,30) | 3.857 | .059 | .612 | .477 |
| Interaction | (1,30) | .429 | .518 | NS | .097 | |
| Arm of Study | (1,30) | 1.098 | .303 | NS | .174 | |
| SDS | SDS - Trend | (1,30) | 47.389 | <.001 | .313 | 1.00 |
| Interaction | (1,30) | .013 | .909 | NS | .051 | |
| Arm of Study | (1,30) | .243 | .625 | NS | .077 | |
| HAM-D | HAM-D - Trend | (1,30) | 3.369 | .076 | .321 | .427 |
| Interaction | (1,30) | 2.299 | .140 | NS | .312 | |
| Arm of Study | (1,30) | 2.698 | .111 | NS | .356 | |
| HAM-A | HAM-A - Trend | (1,30) | 2.695 | .111 | .114 | .356 |
| Interaction | (1,30) | .802 | .378 | NS | .140 | |
| Arm of Study | (1,30) | 2.847 | .102 | NS | .372 |
Trend refers to trend over time across arms; significance indicates that by combining placebo and active scores together scores at one time point were higher than scores at the other time point regardless of arm of the study;
Interaction tests whether there is an interaction between scores at baseline versus endpoint (i.e. slope of line) and the arm of the study;
Arm of the study tests whether one group’s average scores are higher than the other group across time points.
Abbreviations: NE-YBOCS = Yale Brown Obsessive Compulsive Scale Modified for Neurotic Excoriation; SP-SAS = Skin Picking Symptom Assessment Scale; CGI = Clinical Global Impression severity scale; SDS= Sheehan Disability Scale; HAM-D= Hamilton Depression Scale; HAM-A= Hamilton Anxiety Scale