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. Author manuscript; available in PMC: 2012 Sep 7.
Published in final edited form as: Cell Metab. 2011 Sep 7;14(3):324–338. doi: 10.1016/j.cmet.2011.06.020

Figure 6.

Figure 6

BDNF inhibition blocks the EE-induced WAT to BAT transformation. (A) Increase of adiposity occurred before weight increase in BDNF+/− mice compared to wild-type littermates. n=4 per group. ** P<0.01, + P<0.06. (B) RWAT gene expression profile of BDNF+/− mice compared to wild type litter mates (n=4 per group). P values are shown above the bars. (C) TrkB.T1-expressing mice were equally obese as DIO mice expressing YFP (n=5 per group). (D) RWAT gene expression profile of TrkB.T1-expressing mice compared to lean YFP control mice fed with NCD and obese YFP mice fed with HFD (n=5 per group). (E) microRNA targeting BDNF blocked EE-associated molecular features of RWAT (n=4 per group. Con: control housing, Enr: EE housing). Bars not connected by same letter are significantly different. Data are means±SEM. See also Figure S5.