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The SOCS box includes a consensus Elongin BC binding site. (A) Sequence alignment of the Elongin BC binding site regions of VHL and Elongin A proteins from mammalian cells, C. elegans, and S. cerevisiae. (B) The SOCS-box regions of several SOCS-box proteins (Hilton et al. 1998) are aligned beneath Elongin BC binding sites from VHL and Elongin A proteins. (C) Diagrammatic representation of Elongin A, VHL, and the SOCS-box proteins used in this study.
