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. Author manuscript; available in PMC: 2011 Sep 14.
Published in final edited form as: J Invest Dermatol. 2011 Feb 17;131(6):1308–1312. doi: 10.1038/jid.2011.12

Figure 1. Genome-wide association results for generalized vitiligo age of onset.

Figure 1

The genome-wide distribution of −log10(P-values) from the unadjusted linear regression analysis for 520,460 polymorphic single-nucleotide polymorphisms (SNPs) that passed quality control (QC) filters in 1,339 unrelated generalized vitiligo patients is shown plotted across the chromosomes. The dotted line indicates the genome-wide significance criterion (P<5×10−8). The inset shows quantile–quantile (Q–Q) plots of the observed versus expected −log10(P-values) for unadjusted linear regression statistics. The plot in red shows P-values for all 520,460 SNPs, whereas the plot in blue shows P-values excluding the 3,400 SNPs located across the extended major histocompatibility complex (MHC; chromosome 6: 25.9–33.4 Mb, genome build GRCh37).